If you’re looking for a sandwich that combines the smoky, tender goodness of slow-cooked beef with ooey-gooey cheese and crispy bread, then this Southern Brisket Grilled Cheese Recipe is going to rock your world. It’s the perfect balance of rich brisket, melty cheddar and Monterey Jack cheeses, tangy barbecue sauce, and buttery sourdough crisped to golden perfection. Whether you’re craving comfort food or looking to wow your friends at a casual gathering, this sandwich brings all the flavors you love with a Southern twist that feels both classic and totally irresistible.
Ingredients You’ll Need
Creating the ultimate Southern Brisket Grilled Cheese Recipe depends on a handful of simple, quality ingredients that make every bite sing. Each component adds its own magic—from the crusty, buttery sourdough that crunches satisfyingly to the smoky, tender brisket and the perfect blend of cheeses that melt just right.
- 4 slices thick-cut sourdough bread: Provides a sturdy, flavorful base with a golden crust that holds up to all that filling.
- 2 tablespoons butter (softened): Essential for that irresistible golden-brown toast on the outside.
- 1 cup shredded cheddar cheese: Sharp and tangy, it adds depth and richness.
- 1 cup shredded Monterey Jack cheese: Smooth and creamy, perfect for melting beautifully.
- 1 ½ cups cooked beef brisket (shredded or sliced thin): The star ingredient, bringing smoky, tender flavor and hearty texture.
- ½ cup barbecue sauce: Adds a sweet and tangy kick that ties everything together.
- 4 pickle slices (optional): For a crunchy, tangy contrast that brightens each bite.
- Sliced red onion (optional): Gives a subtle sharpness and freshness.
How to Make Southern Brisket Grilled Cheese Recipe
Step 1: Prepare Your Bread and Butter
Start by spreading butter evenly on one side of each slice of sourdough. This step is crucial because it ensures a perfectly crispy and golden crust. When you place the bread butter-side down on the pan later, you’ll get that flavorful crunch that every grilled cheese dreams of.
Step 2: Layer the Cheese and Brisket
On two of the buttered bread slices (butter side down), layer a mix of shredded cheddar and Monterey Jack cheese. Next, pile on your luscious brisket, then drizzle with barbecue sauce for that sweet-smoky punch. If you’re feeling adventurous, add pickles or sliced red onions to brighten and balance the richness. Top it all with another layer of cheese to bind everything as it melts.
Step 3: Assemble the Sandwich
Place the remaining two slices of bread on top, butter side facing up. This sandwich is basically a cozy cheesy brisket bundle ready to get golden and bubbly.
Step 4: Cook to Perfection
Heat a skillet or griddle over medium heat and carefully place your sandwiches in the pan. Cook for 3 to 4 minutes per side, applying gentle pressure with a spatula. This helps the cheese melt evenly and creates that trademark golden crust. When the bread is perfectly toasted and the cheese is melting luxuriously, it’s ready to come off the heat.
How to Serve Southern Brisket Grilled Cheese Recipe
Garnishes
A few fresh garnishes can elevate this sandwich beautifully. Consider a sprinkle of chopped fresh parsley or a handful of crispy fried onions on top to add texture and color. A small ramekin of extra barbecue sauce on the side is always a welcomed dip to amplify those smoky flavors.
Side Dishes
This sandwich pairs wonderfully with classic Southern sides like creamy coleslaw, tangy baked beans, or even a simple mixed green salad with a bright vinaigrette. The freshness of these sides balances out the richness of the sandwich perfectly and rounds out the meal.
Creative Ways to Present
For a fun twist, cut your Southern Brisket Grilled Cheese Recipe into smaller sliders to share at game day or parties. You can also serve it open-faced topped with an extra drizzle of barbecue sauce and some pickled jalapeños for a spicy kick. Wrapping it up in parchment paper and tying with twine adds a rustic, picnic-ready vibe.
Make Ahead and Storage
Storing Leftovers
If you have leftovers, wrap the sandwiches tightly in foil or plastic wrap and store in the refrigerator for up to 2 days. To keep the bread from getting soggy, store components separately if possible and assemble fresh before reheating.
Freezing
For longer storage, you can freeze the assembled sandwiches by wrapping each tightly in plastic wrap and then foil. Freeze for up to 1 month. Just thaw overnight in the refrigerator before reheating for best results.
Reheating
Reheat leftovers in a skillet over medium-low heat to gently warm and revive the crispy bread. If you prefer, use a toaster oven at 350°F for about 10 minutes. Avoid microwaving if you want to keep that glorious grilled texture intact.
FAQs
Can I use other types of bread for this recipe?
Absolutely! While thick-cut sourdough is perfect for its texture and flavor, you can swap in Texas toast, brioche, or even a rustic country loaf depending on what you love or have on hand.
Is it necessary to use both cheddar and Monterey Jack cheese?
Using both cheeses creates a beautiful balance—cheddar brings sharp tang, while Monterey Jack melts with a creamy smoothness. However, feel free to use all cheddar or all Monterey Jack if you prefer.
Can I make this sandwich spicy?
Definitely! Add sliced jalapeños, a dash of hot sauce to the barbecue sauce, or sprinkle some crushed red pepper flakes inside before grilling to turn up the heat.
What’s the best brisket to use?
The best brisket for this recipe is leftover smoked or slow-cooked beef brisket that’s tender and flavorful. Shredded or thinly sliced brisket both work wonderfully depending on your texture preference.
Can this recipe be doubled or scaled up for a crowd?
Yes! This Southern Brisket Grilled Cheese Recipe scales up easily. Just keep the ingredient ratios consistent and cook sandwiches in batches on your skillet or griddle.
Final Thoughts
Trust me when I say this Southern Brisket Grilled Cheese Recipe is going to become one of your go-to meals whenever you want comfort food with a little Southern soul. It’s hearty, flavorful, and downright addictive. So grab your brisket, cheeses, and your favorite bread, and get ready for a grilled cheese experience that’s anything but ordinary. Your taste buds are in for a real treat!
Print
Southern Brisket Grilled Cheese Recipe
- Prep Time: 10 minutes
- Cook Time: 10 minutes
- Total Time: 20 minutes
- Yield: 2 sandwiches
- Category: Main Course
- Method: Stovetop
- Cuisine: Southern American
- Diet: Nut-Free
Description
A mouthwatering Southern Brisket Grilled Cheese that combines tender, smoky beef brisket with melted cheddar and Monterey Jack cheeses, layered between buttery toasted sourdough. Enhanced with tangy barbecue sauce and optional pickles or red onions, this sandwich offers the perfect balance of smoky, savory, and creamy flavors for a comforting meal.
Ingredients
Bread and Butter
- 4 slices thick-cut sourdough bread
- 2 tablespoons butter, softened
Cheese
- 1 cup shredded cheddar cheese
- 1 cup shredded Monterey Jack cheese
Meat and Toppings
- 1 ½ cups cooked beef brisket, shredded or sliced thin
- ½ cup barbecue sauce
- 4 pickle slices (optional)
- Sliced red onion (optional)
Instructions
- Prepare the Bread: Spread the softened butter evenly on one side of each slice of sourdough bread. Place the bread slices butter-side down on a clean surface to assemble the sandwich.
- Layer the Cheese: On two of the bread slices, layer equal amounts of shredded cheddar and Monterey Jack cheese to create a cheesy base.
- Add the Brisket and Toppings: Top the cheese with the cooked beef brisket, then drizzle with barbecue sauce. Add pickle slices or sliced red onion if using for extra flavor and crunch.
- Top with Cheese and Bread: Place the remaining shredded cheese over the brisket, then cover with the remaining bread slices, butter-side up, to complete the sandwich assembly.
- Cook the Sandwiches: Heat a skillet or griddle over medium heat. Place the assembled sandwiches in the pan and cook for 3 to 4 minutes on each side. Press gently with a spatula to ensure even browning and melting of the cheese. Cook until the bread is golden brown and the cheese is fully melted.
- Serve Hot: Remove the grilled sandwiches from heat, slice each in half, and serve immediately while warm and gooey.
Notes
- Use leftover smoked or slow-cooked brisket for maximum flavor depth.
- Swap sourdough with Texas toast or brioche for a softer texture.
- Add a touch of hot sauce or jalapeños for a spicy kick.
